The Influence of Leukemia Inhibitory Factor on Cardiomyogenesis: Implications for Stem Cell-Based Therapy of the Diseased Heart - Softcover

Wiedner, Marc

Softcover

ISBN 10: 3639301838 ISBN 13: 9783639301830

Publisher: VDM Verlag Dr. Müller, 2010

Synopsis

Heart failure represents one of the leading causes of death in western civilization and is primarily the result of previous myocardial infarction. The fact that cardiac tissue is unable to regenerate after infarction led to the general belief that the heart of mammalian species is a terminally differentiated organ. Recently, however, evidence has emerged that the adult heart contains myocardial cells possessing stem cell-like properties, which may have the potential to repair damaged tissue. The identification of factors which could activate these quiescent cardiac stem cells and cause them to differentiate into functional cardiomyocytes would be an important step towards finding new therapies for the treatment of heart diseases. The experiments conducted in this study reveal that leukemia inhibitory factor (LIF) can be utilized as a factor to trigger expansion of cardiac stem cells and induce differentiation into functional heart cells in vitro, which may ultimately prove useful for cell therapy of the diseased heart.

About this title

About the Author

Marc Wiedner (Mag.rer.nat.) studied Molecular Biology at the University of Vienna, specializing in the fields of Molecular Medicine, Immunology and Cell Biology. He currently works as a Biomedical Scientist at the Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.

Edition details

• Publisher: VDM Verlag Dr. Müller
• Publication date: 2010
• Language: English
• ISBN 10: 3639301838
• ISBN 13: 9783639301830
• Binding: Paperback
• Number of pages: 104