Gamma-Secretase and Its Substrates: A Bioinformatics Approach - Softcover

Nan, Fei

Softcover

ISBN 10: 3639102126 ISBN 13: 9783639102123

Publisher: VDM Verlag Dr. Müller, 2008

Synopsis

Gamma-secretase is an enzymatic complex critical to amyloid formation and other important pathophysiological processes. Non-specific gamma-secretase inhibitors are not ideal for intervention of familial Alzheimer¿s disease. Also gamma-secretase cleaves a variety of substrates. But different sites are cleaved even in a single substrate and no consensus sequence for cleavage by gamma-secretase is identified. We hypothesize that consensus compositional sequence in components of gamma-secretase and its substrates should exist during gamma-secretase regulation and specific gammasecretase inhibitor based on such consensus sequence may act as a therapeutic intervention for familial Alzheimer¿s disease. There are two stages in our research. First, We find the candidates by the methods of bioinformatics. Then, we use the traditional biological methods to verify the critical role of the candidates including the protein purification, recognition, and functional domain interaction. The book can serve as reference for computational biology-oriented professionals in advanced research development.

About this title

About the Author

Ph.D.: Computer Science at West Virginia University (2008), M.S.: Microbiology and Immunology at West Virginia University (2008), B.Eng.: Computer Science at Northeastern University (2002). Member of Sigma Xi, IEEE and ACM. Software Engineer at Microsoft Corporation, Redmond, Washington.

Edition details

• Publisher: VDM Verlag Dr. Müller
• Publication date: 2008
• Language: English
• ISBN 10: 3639102126
• ISBN 13: 9783639102123
• Binding: Paperback
• Number of pages: 72