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Synopsis
This is an exploration of the labyrinth of DNA and RNA structural studies. Saenger deals with all the fundamental business of conformational nomenclature and crystallographic esoterica. He explores the many structural hypotheses, but does not confuse these with experimentally well-founded models.
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Review
From the Reviews of the First Edition: "From time to time one reads a book or an account of an experiment and wishes, with more pleasure than envy, that one had produced it oneself. Wolfram Saenger's book is such a virtuoso production: well written, profusely illustrated and astonishingly comprehensive. In it, fact and hypothesis are distinguished with rare scrupulousness. Any serious student or researcher will find it a mine of information. The merely curious now have a guidebook with which safely to explore the labyrinth of DNA and RNA structural studies. Particularly praiseworthy is the way Saenger has managed to deal thoroughly but interestingly with all the fundamental business of conformational nomenclature and crystallographic esoterica. He has not failed to explore the many structural hypotheses still twisting slowly in the wind, but almost nowhere does he confuse these with experimentally well-founded models. ...Current X-ray structural studies focus on oligonucleotides in single crystals and in poly(oligonucleotides) in fibres. These structures are less regular. Whether or not the excursions from regularity are related to base sequences is a lively issue. More ambitiously - and perhaps more wisely - there are increasingly successful studies of DNA bound to histones and other proteins which will reveal specifically how variety and variability in the genetic material can be exploited biologically. Among all its other riches, Saenger's book makes us aware of these too." Nature#1
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Principles of Nucleic Acid Structure
Published by
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 1984
ISBN 10: 3540907629
ISBN 13: 9783540907626
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