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Transporters as Targets for Drugs: 4 (Topics in Medicinal Chemistry, 4) - Hardcover
Book 3 of 38: Topics in Medicinal Chemistry
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M. Bingham • S. Napier: Overview: Transporters as Targets for Drug Discovery
I. Sylte • A.W. Ravna • G. Sager • S.G. Dahl: Membrane Transporters: Structure, Function and Targets for Drug Design
G.A. Whitlock • M.D. Andrews • A.D. Brown • P.V Fish • A. Stobie • F. Wakehut: Design of Monoamine Reuptake Inhibitors – SSRIs, SNRIs and NRIs
A. Hauck Newman • J.L. Katz: Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine’s Mechanism at the Dopamine Transporter
Z. Chen • J. Yang • P. Skolnick: The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors
G. Antoni • J. Sörensen • H. Hall: Molecular Imaging of Transporters with Positron Emission Tomography
R. Bridges • S.A. Patel: Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System xc
R. Gilfillan • J. Kerr G. • Walker • G. Wishart: Glycine Transporters and Their Inhibitors
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TRANSPORTERS AS TARGETS FOR DRUGS (TOPICS IN MEDICINAL CHEMISTRY)
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Transporters as Targets for Drugs
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Transporters as Targets for Drugs (eng)
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Transporters as Targets for Drugs
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Condition: Sehr gut. Zustand: Sehr gut | Seiten: 268 | Sprache: Englisch | Produktart: Bücher | Transporters are proteins that span the plasma membrane and regulate the traf?c of small molecules in and out of the cell. They play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. In most systems the termination of chemical transmission is achieved by rapid uptake of the transmitter molecule from the synapse by transporters located on the synaptic terminal or surrounding glial cells. Another key role for transporters is in excluding undesirable xenobiotics from the cell, whilst allowing key molecules required for the cell life cycle to enter. It is incre- ingly recognised that these ef?ux or uptake transporters respectively, play an important role in the disposition of many marketed drugs, and whilst the ?eld of drug transport is yet to attain the level of maturity of drug metabolism,itiscertaintobeofincreasingimportance infuturedrugdisc- ery programmes. 2 Transporter Classification Transporters can be classed into two main families; the ATP binding c- sette (ABC) family, and the solute carrier (SLC) family. The SLC family is a very broad categorisation which encompasses, amongst others, three - portant families of transporters for organic molecules; the major facilitator superfamily (MFS) and two neurotransmitter transporter families, the neu- transmitter; sodium symporter (NSS, or SLC6) and the dicarboxylate/amino + + acid:cation (Na or H ) symporter (DAACS, or SLC1) family. Seller Inventory # 4741272/12
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Transporters as Targets for Drugs
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Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. With contributions by numerous experts|In each volume an overview chapter introduces the newcomer to the topic coveredSeries covers hot topics of frontier research summarized by reputed scientists in the fieldReview series is topic related. Seller Inventory # 4901737
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Transporters as Targets for Drugs
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -M. Bingham - S. Napier: Overview: Transporters as Targets for Drug DiscoveryI. Sylte - A.W. Ravna - G. Sager - S.G. Dahl: Membrane Transporters: Structure, Function and Targets for Drug DesignG.A. Whitlock - M.D. Andrews - A.D. Brown - P.V Fish - A. Stobie - F. Wakehut: Design of Monoamine Reuptake Inhibitors - SSRIs, SNRIs and NRIsA. Hauck Newman - J.L. Katz: Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter Z. Chen - J. Yang - P. Skolnick: The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake InhibitorsG. Antoni - J. Sörensen - H. Hall: Molecular Imaging of Transporters with Positron Emission TomographyR. Bridges - S.A. Patel: Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System xcR. Gilfillan - J. Kerr G. - Walker - G. Wishart: Glycine Transporters and Their Inhibitors 268 pp. Englisch. Seller Inventory # 9783540879114
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