Systemic Radiotherapy with Monoclonal Antibodies: Options and Problems: 141 (Recent Results in Cancer Research) - Hardcover

Hardcover

ISBN 10: 3540602097 ISBN 13: 9783540602095

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1996

Synopsis

Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio- labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

About this title

Review

"a timely and deliberately provocative new impetus to this long overdue discussion of promising, selective cancer treatment." Jnl. of the National Cancer Institute

Synopsis

This text is concerned with various options and problems in systemic radiotherapy with monoclonal antibodies. Topics covered include high dose radioimmunotherapy in malignant lymphoma and the treatment of patients with recurrent malignant gliomas with intratumoural radioimmunoconjugates.

Edition details

• Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Publication date: 1996
• Language: English
• ISBN 10: 3540602097
• ISBN 13: 9783540602095
• Binding: Hardcover
• Number of pages: 198
• Editor: Sautter-Bihl Marie-Luise, Bihl Heiner, Wannemacher Michael