Pre-MRNA Processing (Molecular Biology Intelligence Unit) - Hardcover

Hardcover

ISBN 10: 3540590811 ISBN 13: 9783540590811

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1995

Synopsis

he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func- tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.

About this title

Synopsis

This volume explores the formation of functional mRNA from primary gene transcripts (pre-mRNA) in eukaryotic cells. It concentrates on the major RNA processing reactions that generate spliced and polyadenylated mRNA in the nucleus. The last ten years have seen a tremendous growth in our understanding of the splicing and polyadenylation mechanisms and new processing reactions, such as RNA editing, have been discovered. Individual chapters review RNA structure, protein-RNA interactions and biochemical and genetic studies in mammalian, yeast and plant cells that have contributed to our current picture of how mRNA is formed and transported to the cytoplasm. Other chapters discuss new insights into the mechanisms of viral infection and inherited disease that have emerged from research in the RNA processing field.

Edition details

• Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Publication date: 1995
• Language: English
• ISBN 10: 3540590811
• ISBN 13: 9783540590811
• Binding: Hardcover
• Number of pages: 233
• Editor: Lamond Angus I.