Progress in Fibrin Sealing - Softcover

 
9783540507970: Progress in Fibrin Sealing

Synopsis

Fibrin plays a central role in wound healing. It has a hemostatic effect by forming a temporary wound closure and assists in neovascularization and fibroblast prolifera- tion. It therefore makes the repair of injured or severed parts of the human body by simple glueing possible, a notion that men have dreamed of since ancient times. The first modern attempts in this direction, using clotting substances derived from human blood to achieve hemostasis, were reported by Bergel (in 1909), Grey (in 1915), and Harvey (in 1916), who used fibrin powder or fibrin patches to control bleeding from parenchymatous organs. Two decades later Young and Medawar (1940) and Cronkite (1944) used blood plasma or fibrin solutions, adding thrombin to seal nerve anastomoses and to fix skin grafts in humans. Due to the poor adhesive strength of the fibrinogen the results were unsatisfactory. In 1972 a new era in fibrin sealing was initiated by Matras. By using highly concentrated fibrinogen in combination with factor XIII (fibrin-stabilizing factor) and by delaying fibrinolysis with a fibrinolysis inhibitor (aprotinin), a method was developed which after satisfactory results in animals, soon began to be applied in humans.

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Product Description

This volume presents the experimental and clinical assessment of fibrin sealing in endoscopy. It is based on a Symposium held in Salzburg, December 1988 and updates information availabe since the first symposium held in Vienna, 1985. Results show that, since fibrin sealing came into clinical use 13 years ago, it has become an accepted tool in many fields of surgery and increased postoperative safety. The indications and limitations of new methods are discussed here, specifically, fibrin sealing for the endoscopic closure of broncho-pleural and gastro-intestinal fistulae, for the endoscopic hemostasis of bleeding gastro-duodenal ulcers, and for the occlusion of the pancreatic duct.

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Other Popular Editions of the Same Title

9783642483639: Progress in Fibrin Sealing

Featured Edition

ISBN 10:  3642483631 ISBN 13:  9783642483639
Publisher: Springer, 2012
Softcover