Cell Kinetic Modelling and the Chemotherapy of Cancer: 75 (Lecture Notes in Biomathematics, 75) - Softcover

Knolle, Helmut

 
9783540501534: Cell Kinetic Modelling and the Chemotherapy of Cancer: 75 (Lecture Notes in Biomathematics, 75)
Softcover
ISBN 10: 3540501533 ISBN 13: 9783540501534
Publisher: Springer, 1988

Synopsis

During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re­ levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).

"synopsis" may belong to another edition of this title.

Product Description

During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re­ levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).

"About this title" may belong to another edition of this title.

Publisher
Springer
Publication date
1988
Language
English
ISBN 10 
3540501533
ISBN 13 
9783540501534
Binding
Paperback
Edition number
1
Number of pages
165

Other Popular Editions of the Same Title

9780387501536: Cell Kinetic Modelling and the Chemotherapy of Cancer (Lecture Notes in Biomathematics)

Featured Edition

ISBN 10:  0387501533 ISBN 13:  9780387501536
Publisher: Springer Verlag, 1988
Softcover