Tissue-Specific Estrogen Action: Novel Mechanisms, Novel Ligands, Novel Therapies: 2006/1 (Ernst Schering Foundation Symposium Proceedings, 2006/1) - Hardcover

Hardcover

ISBN 10: 3540495479 ISBN 13: 9783540495475

Publisher: Springer, 2007

Synopsis

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s―and therefore several decades longer than nuclear receptor - searchitself―estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.

About this title

Product Description

Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.

Review

From the reviews:

"This summation of a symposium discusses some of the new research developments and estrogen-receptor based therapies that are being tested in the laboratory and in current use. ... It is written for researchers, physician scientists, and those interested in estrogen receptor interactions at a molecular level. Hopefully, it can also stimulate interest in and future research by graduate students or clinical/basic researchers." (Amber R. Cooper, Doody’s Review Service, January 2008)

Edition details

• Publisher: Springer
• Publication date: 2007
• Language: English
• ISBN 10: 3540495479
• ISBN 13: 9783540495475
• Binding: Hardcover
• Number of pages: 196
• Editor: Korach Kenneth S., Wintermantel Tim