Data Mining in Structural Biology: Signal Transduction and Beyond: v. 34 (Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements) - Hardcover
Synopsis
This work combines biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It describes how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed.
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Synopsis
This work combines biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It describes how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed.
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Ernst Schering Research Foundation Workshop - 34: Data Mining in Structural Biology: Signal Transduction and Beyond
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Hardcover. Condition: Fine. Abnutzung / Risse - leicht; Vergilbt / ausgeblichen. Structural biology is increasingly becoming a standard technique for structure determination in the pharmaceutical industry. Advances in molecular biology, crystal handling, data collection, tunable synchrotron radiation sources, and high-performance computing have facilitated the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperatures. The Protein Databank has seen a remarkable increase in protein structure deposits, with over 1,500 structures submitted annually since 1997. In just the first seven months of this year, another 1,500 structures were added. Global initiatives in "structural genomics" have led to high-throughput structure determination techniques, further boosting the number of three-dimensional protein structures identified. This structural information plays a crucial role in drug discovery, being utilized not only in structure-based drug design for new low-molecular-weight ligands but also in the early stages of target validation and assessment. As the number of protein sequences lacking significant homology to known proteins grows, structure-sequence compatibility (threading) is increasingly employed to assign functions to specific protein folds. Seller Inventory # e07d1d1f-bbe4-4272-a694-a16e4890e756
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Data Mining in Structural Biology. Signal Transdution and Beyond. With 37 Figures and 14 Tables. [= Ernst Schering Research Foundation Workshop 34].
Seller: Antiquariat Fluck, Berlin, Germany
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Original-Pappband; 8°; XIII (I) 205 (5) Seiten. Sehr gutes Exemplar. Sprache: Englisch Ernst Schering Research Foundation Workshop 34. 450 gr. Seller Inventory # 48224
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Data Mining in Structural Biology: Signal Transduction and Beyond (Ernst Schering Foundation Symposium Proceedings 34)
Seller: Zubal-Books, Since 1961, Cleveland, OH, U.S.A.
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Condition: Good. 205 pp., Hardcover, ex library, else text clean and binding tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country. Seller Inventory # ZB897947
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Data Mining in Structural Biology. : Signal Transduction and Beyond.
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Springer-Verlag GmbH & Co. KG, 2001
ISBN 10: 3540414940
ISBN 13: 9783540414940
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Condition: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar. Seller Inventory # 213291/202