Cell Adhesion: 165 (Handbook of Experimental Pharmacology, 165) - Hardcover

Hardcover

ISBN 10: 3540209417 ISBN 13: 9783540209416

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2004

Synopsis

As with other areas of biological research, the progress that has been made over the past 25 years in the field of cell adhesion is impressive. In the late 1970s, the searchfor specific cell surface receptors for adhesion processes was initiated - ing mainly biochemical and immunological approaches. Since then, theint- duction of novel methods of cellular and molecular biology and powerful te- niques for manipulatinggene expression in transgenic and knock-out mice have greatlyadvanced the field. Not only dowe now know the precise molecular structure of many of thecell adhesion receptors that were postulated to exist in the early days, but we have a clear picture of their function, and evidence of their involvement in signal transduction. We have also found clues to the role of cell adhesion in normal embryonal development and adult physiology, and we have evidence that disturbance in cell adhesion can cause disease. In this volume, our goal was to provide an overview of the main topics of c- rent cell adhesion research, including structural analyses of cell adhesion mo- cules and studies of their functionalrole in vitroand in vivo. We have focussed mainly on the four major families of cell-adhesion receptors, i. e. the cadherins, the integrins, the Ig superfamily and the selectin-based adhesion system. The chapters by Perez and Nelson and Choi and Weis describethe structuralbasis of cadherin function, focussing on the extracellular domain of cadherins and thecytoplasmic tail interactions with catenins, respectively.

About this title

Synopsis

This book provides an overview of the main topics of current cell adhesion research including structural analyses of cell adhesion molecules and studies to their functional role in vitro and in vivo. The present volume focuses on the four major families of cell-adhesion receptors, i. e. the cadherins, the integrins, the Ig-superfamily and the selectin-based adhesion system which are discussed in detail by numerous experts in the field.

Edition details

• Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Publication date: 2004
• Language: English
• ISBN 10: 3540209417
• ISBN 13: 9783540209416
• Binding: Hardcover
• Number of pages: 492
• Editor: Behrens Jürgen, Nelson Warren James