Treatment of Multiple Sclerosis: Trial Design, Results and Future Perspectives (Clinical Medicine and the Nervous System) - Hardcover

Hardcover

ISBN 10: 3540196838 ISBN 13: 9783540196839

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1992

Synopsis

Multiple sclerosis is one of the major current problems in neurol- ogical practice. It remains incompletely understood, yet is a common cause of chronic disability in developed Western so- cieties: Patients with the disease have difficulty understanding what has happened to them and become bewildered by the con- trast between the evidently large body of knowledge concerning the clinical manifestations and course of the disease, and the conflicting views they so often receive from different specialists as to the best current management of their disease. As in so many disorders for which treatment is only partially effective, at best, "alternative" therapies abound. Dr. Rudick and Dr. Goodkin have extensive experience in the day-to-day management of multiple sclerosis at the Mellen Center for Multiple Sclerosis Treatment and Research, attached to the Cleveland Clinic. In this book they have assembled a group of experts from several countries and have provided a comprehensive review of the results of different treatments of the disease. Each treatment is considered in the light of its proposed scientific basis or mode of action, and in relation to ethical and trial design issues. This information deserves to be made widely available. As the treatment of multiple sclerosis enters a new era as a result of the new understanding of the cellular mechanisms of demyelination and the molecular biology of the immune response, this information about current treatments assumes additional importance. The book is of interest to all physicians concerned with the management of patients with the disease.

About this title

Synopsis

Experimental trials that have captured current interest and hold the promise of future advances in the treatment of multiple sclerosis are covered in this monograph. The authors review the statistical and design aspects of experimental therapy as well as the emerging concepts of pathogenesis which have already begun to modify present approaches. The monograph gives a better understanding of the many recent advances in the field. These include improved statistical knowledge and design that will permit results from properly conducted clinical trials; an understanding of the mechanisms of organ-specific tissue injury in experimental allergic encephalomyelitis and multiple sclerosis; and numerous trials of experimental immunotherapy in the disease.

Edition details

• Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Publication date: 1992
• Language: English
• ISBN 10: 3540196838
• ISBN 13: 9783540196839
• Binding: Hardcover
• Number of pages: 331
• Editor: Rudick R. A., Goodkin D. E.