Oncogenes in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 5-7, 1984: 113 (Current Topics in Microbiology and Immunology) - Hardcover

Hardcover

ISBN 10: 3540135979 ISBN 13: 9783540135975

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1984

Synopsis

Michael Potter, Fritz Melchers, Martin Weigert The second workshop on Mechanisms of B Cell Neoplasia was held in Bethesda, Maryland in Wilson Hall at the National Institutes of Health on March 5, 6, and 7, 1984. It followed a workshop on the same topic that was held at the Basel Institute for Immunology, March 15-17, 1983. That first meeting attempted to bring together cell biologists, experimental pathologists and molecular geneti­ cists interested in B cells, to discuss pathogenetic processes in the development and maintenance of the neoplastic state. The impetus for this discussion emanated from two important developments: first, the discovery of the viral promoter insertion mechanism for acti­ vating the myc oncogene in bursal lymphomatosis by Hayward, Neil, and Astrin;-second, the findings that the non-random chromosomal trans locations involving the immunoglobulin gene chromosomes occur­ red in very high frequencies in murine plasmacytomas and human Burkitt's lymphomas. During the planning stages of that meeting Shen-Ong et al. discovered that non-random translocations activated the myc oncogene. Promoter insertions and non-random trans locations were-rwo mechanisms that caused transcription of the myc oncogene messages in three different kinds of well defined experimental and clinical B cell tumors. Unregulated myc gene transcription provided the first evidence of a specific bioChemical lesion in B cell neo­ plasia.

Edition details

• Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Publication date: 1984
• ISBN 10: 3540135979
• ISBN 13: 9783540135975
• Binding: Hardcover
• Language: English
• Number of pages: 281
• Editor: Potter M., Melchers F., Weigert M.