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Steric Fit in Quantitative Structure-Activity Relations: 15 (Lecture Notes in Chemistry, 15) - Softcover
Synopsis
Although the importance of steric fit for receptor-effector 1 interactions was recognized since Emil Fischer proposed his "lock and key" theory, the whole area of steric properties is still in a very 2-4 early stage of development. We have a fairly good idea about el- tronic and hydrophobic parameters, but it is not easy to describe ste- ric shapes of molecules without a large number of data. There are se- veral cases of good QSAR's developed for rather large series of mole- 5 cules without steric parameters - for example see papers by Hansch , 6 or Franke , but the state of steric parameters is nevertheless one of the most important drawbacks, especially concerning the ability of en- compassing, within a single QSAR, molecules of different shapes and stereoisomers. From today's steric parameters, one may mention the 7 Taft parameters E ' which gave good results in organic chemistry, the S 8 10 ra th er cum b ersome way 0 f measurIng * s h ape d'ff I ere h ces 0 f Amoore - and , 11 12 AllInger ,and the L, B -B parameters of Verloop 1 4 The work described here consists of two types of approaches to the steric fit problem. The first approach consists of developing new parameters to describe different characteristics of the molecular shape (i. e. , branching, bulkiness); this is done by means of topological in- dices.
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Steric fit in quantitative structure-activity relations
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ISBN 10: 3540097554
ISBN 13: 9783540097556
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Steric Fit in Quantitative Structure-Activity Relations
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Steric Fit in Quantitative Structure-Activity Relations (Lecture Notes in Chemistry, 15)
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Steric Fit in Quantitative Structure-Activity Relations
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Springer Berlin Heidelberg, 1980
ISBN 10: 3540097554
ISBN 13: 9783540097556
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Although the importance of steric fit for receptor-effector 1 interactions was recognized since Emil Fischer proposed his 'lock and key' theory, the whole area of steric properties is still in a very 2-4 early stage of development. We have a fairly good idea about el- tronic and hydrophobic parameters, but it is not easy to describe ste ric shapes of molecules without a large number of data. There are se veral cases of good QSAR's developed for rather large series of mole- 5 cules without steric parameters - for example see papers by Hansch , 6 or Franke , but the state of steric parameters is nevertheless one of the most important drawbacks, especially concerning the ability of en compassing, within a single QSAR, molecules of different shapes and stereoisomers. From today's steric parameters, one may mention the 7 Taft parameters E ' which gave good results in organic chemistry, the S 8 10 ra th er cum b ersome way 0 f measurIng s h ape d'ff I ere h ces 0 f Amoore - and , 11 12 AllInger ,and the L, B -B parameters of Verloop 1 4 The work described here consists of two types of approaches to the steric fit problem. The first approach consists of developing new parameters to describe different characteristics of the molecular shape (i. e. , branching, bulkiness); this is done by means of topological in dices. Seller Inventory # 9783540097556
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Steric Fit in Quantitative Structure-Activity Relations
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Springer Berlin Heidelberg, 1980
ISBN 10: 3540097554
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Detailed Contents.- 1 Introduction.- 2 Steric and other Structural Parameters for QSAR.- 2.1 Correlational Equations and Predictor Variables.- 2.2 Steric Parameters.- 2.2.1 Taft Type Steric Parameters: ES, ESc, ESo, ESe and v.- 2.2.2 Amoore Type Steric Para. Seller Inventory # 4880625
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Steric Fit in Quantitative Structure-Activity Relations (Lecture Notes in Chemistry)
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Steric Fit in Quantitative Structure-Activity Relations
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ISBN 10: 3540097554
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Although the importance of steric fit for receptor-effector 1 interactions was recognized since Emil Fischer proposed his 'lock and key' theory, the whole area of steric properties is still in a very 2-4 early stage of development. We have a fairly good idea about el- tronic and hydrophobic parameters, but it is not easy to describe ste ric shapes of molecules without a large number of data. There are se veral cases of good QSAR's developed for rather large series of mole- 5 cules without steric parameters - for example see papers by Hansch , 6 or Franke , but the state of steric parameters is nevertheless one of the most important drawbacks, especially concerning the ability of en compassing, within a single QSAR, molecules of different shapes and stereoisomers. From today's steric parameters, one may mention the 7 Taft parameters E ' which gave good results in organic chemistry, the S 8 10 ra th er cum b ersome way 0 f measurIng s h ape d'ff I ere h ces 0 f Amoore - and , 11 12 AllInger ,and the L, B -B parameters of Verloop 1 4 The work described here consists of two types of approaches to the steric fit problem. The first approach consists of developing new parameters to describe different characteristics of the molecular shape (i. e. , branching, bulkiness); this is done by means of topological in dices.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 196 pp. Englisch. Seller Inventory # 9783540097556
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Steric Fit in Quantitative Structure-Activity Relations (Lecture Notes in Chemistry, 15)
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Steric Fit in Quantitative Structure-Activity Relations
Published by
Springer Berlin Heidelberg Apr 1980, 1980
ISBN 10: 3540097554
ISBN 13: 9783540097556
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although the importance of steric fit for receptor-effector 1 interactions was recognized since Emil Fischer proposed his 'lock and key' theory, the whole area of steric properties is still in a very 2-4 early stage of development. We have a fairly good idea about el- tronic and hydrophobic parameters, but it is not easy to describe ste ric shapes of molecules without a large number of data. There are se veral cases of good QSAR's developed for rather large series of mole- 5 cules without steric parameters - for example see papers by Hansch , 6 or Franke , but the state of steric parameters is nevertheless one of the most important drawbacks, especially concerning the ability of en compassing, within a single QSAR, molecules of different shapes and stereoisomers. From today's steric parameters, one may mention the 7 Taft parameters E ' which gave good results in organic chemistry, the S 8 10 ra th er cum b ersome way 0 f measurIng s h ape d'ff I ere h ces 0 f Amoore - and , 11 12 AllInger ,and the L, B -B parameters of Verloop 1 4 The work described here consists of two types of approaches to the steric fit problem. The first approach consists of developing new parameters to describe different characteristics of the molecular shape (i. e. , branching, bulkiness); this is done by means of topological in dices. 196 pp. Englisch. Seller Inventory # 9783540097556
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Steric Fit in Quantitative Structure-Activity Relations (Lecture Notes in Chemistry, 15)
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