The volumes of this series present almost 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto.
The reviews consider carcinogenic medicines, germ cell mutagens, the limitation of exposure peaks, nitrosation of volatile amines at the workplace, passive smoking at work as well as numerous single substances, substance classes and complex mixtures.
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The Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area was called into being by the German Science Foundation in 1955. Its mandate was to continue the development begun by German toxicologists in the last century and to establish a scientific basis for the protection of workers from the adverse effects of toxic chemicals, making recommendations for the establishment of "MAK" values (maximimum concentrations at the workplace) and the classification of carcinogenic substances. Since then the scope of the Commission's activities has been extended, and its recommendations are published annually in the form of evaluation documents. The present volume is the first in a series of English translations of these evaluation documents, including a selection of the Commission's work in the establishment of "MAK" values in the last two years.
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