Protein Purification: Design and Scale Up of Downstream Processing - Hardcover

Wheelwright, Scott M.

9783446157033: Protein Purification: Design and Scale Up of Downstream Processing

Hardcover

ISBN 10: 3446157034 ISBN 13: 9783446157033

Publisher: Carl Hanser Verlag GmbH & Co, 1991

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A comprehensive introduction to the art and science used by the biochemist and process engineer in the design and optimization of large–scale protein–purification processes. Covers the basics of proteins′ properties, the unit operations involved in protein purification as well as important related issues of process design, integration with upstream operations, cost and timing to market. Includes an abundance of figures and tables.

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Synopsis

"Protein Purification" describes general techniques useful for translating industrial bioprocesses from the laboratory to any larger scale. This book is directed towards readers with both biochemical and engineering backgrounds. One of the challenges in this field is the integration of engineering and biology in the design of process systems. This work is designed to facilitate the interaction between these two groups. Backed by practical examples, case studies and extensive literature references, the book aims to offer primary value for technologists whose speciality is the design and optimization of fermentation and cell culture processes for downstream recovery of protein and peptide products. Of use to researchers, engineers, production operators and students, Dr Wheelwright's strategy sets forth practical guidelines and shows how to define product specifications and establish design strategies, specify unit operations, scale up unit operation recovery techniques and optimize purification processes.

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