Lydersen: Large ∗scale∗ Cell Culture Technology - Hardcover

LYDERSEN, BK

 
9783446148451: Lydersen: Large ∗scale∗ Cell Culture Technology

Synopsis

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The Book This book provides the most detailed and comprehensive survey available of the different methods for production of biotechnology products from large scale mammalian and plant cell culture. Methods ranging from fermentation and encapsulation to hollow fibers and fluidized beds are described by the leaders in the field with a section on regulatory considerations. Each production method is described in detail in terms of principles, equipment and results so that informed comparisons and evaluations can be made. Contents Antibody Production with Airlift Fermentors Monoclonal Antibody Production in Stirred Reactors Microcarrier Cell Culture Cellular Microencapsulation for Large–Scale Production of Monoclonal Antibodies Entrapment of Cultured Cells in Agarose Beads An Automated Hollow Fiber System for the Large Scale Manufacture of Mammalian Cell Secreted Product Continuous Cell Culture with Fluidized Sponge Beads Perfusion Cell Culture System Based on Ceramic Matrices Large Scale Plant Cell Culture Safety Considerations for Cell Culture–Derived Biologicals

Synopsis

This book provides a detailed and comprehensive survey of the different methods for production of biotechnology products from large scale mammilian and plant cell culture. It focuses on approaches to the large scale culture of animal and plant cells. Many innovative developments have been made recently with continuous culture, process control, the incorporation of selective membranes and cell immobilization. The chapters detail the important aspects of each approach and provide experimental results showing the practical utility of the approach. A critical evaluation of the different approaches is provided.

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