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Synopsis
Efficacy and safety of anticancer drugs are traditionally studied using cancerous cell lines and animal models. Recently, one of the potential anticancer agents, JQ1 an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase of the cell cycle. However, JQ1’s effect on normal cells is poorly understood. In this study, we investigated the safety of JQ1 by using human umbilical cord mesenchymal stem cells (MSCs) as an in vitro model system. Our results indicated that JQ1 induced cell cycle arrest of MSCs in G1 phase, but did not promote apoptosis. Microarray analysis of MSCs treated with JQ1 indicated that it down-regulated genes involved not only in cell cycle regulation but also DNA replication, mitosis, and cell division. These findings suggest that JQ1 has a deleterious effect on normal cells and may not be safe for anticancer therapy.
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BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells
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Noor Publishing Mrz 2017, 2017
ISBN 10: 333085233X
ISBN 13: 9783330852334
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Efficacy and safety of anticancer drugs are traditionally studied using cancerous cell lines and animal models. Recently, one of the potential anticancer agents, JQ1 an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase of the cell cycle. However, JQ1's effect on normal cells is poorly understood. In this study, we investigated the safety of JQ1 by using human umbilical cord mesenchymal stem cells (MSCs) as an in vitro model system. Our results indicated that JQ1 induced cell cycle arrest of MSCs in G1 phase, but did not promote apoptosis. Microarray analysis of MSCs treated with JQ1 indicated that it down-regulated genes involved not only in cell cycle regulation but also DNA replication, mitosis, and cell division. These findings suggest that JQ1 has a deleterious effect on normal cells and may not be safe for anticancer therapy. 72 pp. Englisch. Seller Inventory # 9783330852334
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BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Alghamdi SaeedSaeed Obaid Alghamdi is a lecturer in the Department of Biological Sciences, Faculty of Science and Arts, King Abdulaziz University, Rabigh, Saudi Arabia.In 2015, Saeed earned a master of science in cellular and molecul. Seller Inventory # 151243352
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BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Seller: Revaluation Books, Exeter, United Kingdom
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Paperback. Condition: Brand New. 72 pages. 8.66x5.91x0.17 inches. In Stock. Seller Inventory # __333085233X
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BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Published by
Noor Publishing Mär 2017, 2017
ISBN 10: 333085233X
ISBN 13: 9783330852334
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Efficacy and safety of anticancer drugs are traditionally studied using cancerous cell lines and animal models. Recently, one of the potential anticancer agents, JQ1 an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase of the cell cycle. However, JQ1's effect on normal cells is poorly understood. In this study, we investigated the safety of JQ1 by using human umbilical cord mesenchymal stem cells (MSCs) as an in vitro model system. Our results indicated that JQ1 induced cell cycle arrest of MSCs in G1 phase, but did not promote apoptosis. Microarray analysis of MSCs treated with JQ1 indicated that it down-regulated genes involved not only in cell cycle regulation but also DNA replication, mitosis, and cell division. These findings suggest that JQ1 has a deleterious effect on normal cells and may not be safe for anticancer therapy.Books on Demand GmbH, Überseering 33, 22297 Hamburg 72 pp. Englisch. Seller Inventory # 9783330852334
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BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Print on DemandSeller: AHA-BUCH GmbH, Einbeck, Germany
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Efficacy and safety of anticancer drugs are traditionally studied using cancerous cell lines and animal models. Recently, one of the potential anticancer agents, JQ1 an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase of the cell cycle. However, JQ1's effect on normal cells is poorly understood. In this study, we investigated the safety of JQ1 by using human umbilical cord mesenchymal stem cells (MSCs) as an in vitro model system. Our results indicated that JQ1 induced cell cycle arrest of MSCs in G1 phase, but did not promote apoptosis. Microarray analysis of MSCs treated with JQ1 indicated that it down-regulated genes involved not only in cell cycle regulation but also DNA replication, mitosis, and cell division. These findings suggest that JQ1 has a deleterious effect on normal cells and may not be safe for anticancer therapy. Seller Inventory # 9783330852334
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BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Seller: preigu, Osnabrück, Germany
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Taschenbuch. Condition: Neu. BET Inhibition Induces Cell Cycle Arrest in Mesenchymal Stem Cells | Saeed Alghamdi | Taschenbuch | 72 S. | Englisch | 2017 | Noor Publishing | EAN 9783330852334 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 108864411