Evaluation of Cypermethrin Toxicity in Lab Mice - Softcover

Islam, M. Saiful; Hoque, Md. Mizanul

Softcover

ISBN 10: 3330055693 ISBN 13: 9783330055698

Publisher: LAP LAMBERT Academic Publishing, 2017

Synopsis

Cypermethrin, being a synthetic pyrethroid insecticide with a fast-acting neurotoxin known to cause free radical-mediated tissue damage in a wide range of animals, has been used here in laboratory albino mice Mus musculus L. to evaluate its toxicity in terms of behavioural and clinical signs, accompanied by morphometric, histopathological and haematological changes in the experimental animals. Male mice (~20g) received 0.10mL-0.25mL-1 body weight cypermethrin intraperitoneally each week for four consecutive weeks. Severe histopathological changes, especially in the liver and kidneys, coupled with weight loss of organs and necrosis of various body parts, were noticeable. Haematological profile of the cypermethrin-treated mice revealed statistically significant decrease in the RBC, platelets, haemoglobin, neutrophils and basophils but increase in the WBC such as lymphocytes, monocytes and eosinophils. Results indicate that cypermethrin is harmful to mammals including human beings and therefore, judicious use of this insecticide should be assured while applying them in agricultural fields and indoor households.

About this title

About the Author

Dr. M. Saiful Islam, Professor, Department of Zoology, Rajshahi University (RU), Bangladesh, specialized in Animal Genetics, Breeding, Molecular Biology & Microbiology; Md. Mizanul Hoque, MS in Biotechnology & Genetic Engineering, Life Science School, Khulna University, Bangladesh, currently pursuing PhD at RU, Bangladesh.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2017
• Language: English
• ISBN 10: 3330055693
• ISBN 13: 9783330055698
• Binding: Paperback
• Number of pages: 124