Asbestos and Mesothelioma (Current Cancer Research) - Softcover

Softcover

ISBN 10: 3319851837 ISBN 13: 9783319851839

Publisher: Springer, 2018

Synopsis

This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma.  Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included.  Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.  Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance.  Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.

About this title

About the Author

Joseph R. Testa, PhD, FACMG is Senior Member/Professor, Carol and Kenneth E. Weg Chair in Human Genetics, Chief of Laboratory Genetics, and Co-Leader of the Cancer Biology Program at Fox Chase Cancer Center, Philadelphia, PA. His research interests focus on mesothelioma pathogenesis and AKT-related oncogenesis. He has published numerous papers and reviews, and serves on the editorial boards of several journals, including as Senior Editor for Cancer Research. He has received multiple science awards, including the J. Christopher Wagner Medal from the International Mesothelioma Interest Group and the Pioneer Research Award from the Mesothelioma Applied Research Foundation. He is also a Fellow of the American Association for the Advancement of Science.

From the Back Cover

This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma.  Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included.  Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.  Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance.  Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.

Edition details

• Publisher: Springer
• Publication date: 2018
• Language: English
• ISBN 10: 3319851837
• ISBN 13: 9783319851839
• Binding: Paperback
• Number of pages: 415
• Editor: Testa Joseph R.