Sickle Cell Anemia: From Basic Science to Clinical Practice - Softcover

Softcover

ISBN 10: 3319791532 ISBN 13: 9783319791531

Publisher: Springer, 2018

Synopsis

Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

About this title

About the Author

Fernando F. Costa - graduated (1974) and obtained both his MSc (1979) and PhD (1981) degrees from the Ribeirăo Preto School of Medicine of the University of Săo Paulo, where he also served as a faculty member (1985-1989). After completing a postdoctoral fellowship at the Yale School of Medicine (1987-1989), he joined the Department of Internal Medicine of the School of Medical Sciences of the University of Campinas (1990) and became a Full Professor of Hematology and Hemotherapy (1996). Member of several national and international academic societies, Professor Costa has already published 260 papers in peer-reviewed journals and supervised 29 doctoral theses. He received a decoration from the Government of Brazil (2008) and has been awarded a great number of scientific prizes, including one from the Government of the State of Săo Paulo (2000). At the University of Campinas, Professor Costa served as Dean of the School of Medical Sciences (1994-1998), Director of the Hematology and Hemotherapy Center (1998-2002), Vice-President for Research (2002-2005) and General Coordinator of the University (2005-2009). He was the president of the University of Campinas from April 2009 to April 2013.
Nicola Conran - Research scientist at the University of Campinas, Brazil. Graduated in Biochemistry (University of Birmingham, UK); PhD, University of Nottingham, UK.

From the Back Cover

Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

Edition details

• Publisher: Springer
• Publication date: 2018
• Language: English
• ISBN 10: 3319791532
• ISBN 13: 9783319791531
• Binding: Paperback
• Number of pages: 450
• Editor: Costa Fernando Ferreira, Conran Nicola