Synopsis
Receptor-cyclic nucleotide microdomains in the heart.- Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes.-Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase Anchoring Proteins.- Pharmacological approaches for delineating functions of AKAP-base signalling complexes and finding therapeutic targets.- Chatting second messengers: PIP3 and cAMP.-Cyclic nucleotide phosphodiesterases and compartmentation in normal and diseased heart.-cAMP compartmentalisation and hypertrophy of the heart: 'good' pools of cAMP and 'bad' pools of cAMP coexist in the same cardiac myocyte.- Subcellular targeting of PDE4 in cardiac myocytes and generation of signaling compartments.- Cardiac cAMP microdomains and their modulation using disruptor peptides.- Computational modelling of cyclic nucleotide signaling mechanisms in cardiac myocytes.- SIGNALING MICRODOMAINS: THE BETA3 ADRENERGIC RECEPTOR/NOS SIGNALOSOME.- Compartmentation of natriuretic peptide signalling in cardiac myocytes - effects on cardiac contractility and hypertrophy.- Cyclic GMP/Protein Kinase Localized Signaling and Disease Implications.- Distribution and regulation of L-type Ca2+ channels in cardiomyocyte microdomains.- The Role of Local Ca2+ Release for Ca2+ Alternans and SR Ca2+ Leak .- The control of sub-plasma membrane calcium signalling by the plasma membrane calcium ATPase pump PMCA4.- Calcium microdomains in cardiac cells.
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