CONTENTS
PART 1. INTRODUCTION/BACKGROUND
1. When and How Did It All Begin? A Brief History of Intravenous Anesthesia
John Sear
2. The Development and Regulation of Commercial Devices for Target - Controlled Drug Infusion
John B Glen
3. The Memory Labyrinth: systems, processes and boundaries
Robert A. Veselis
4. Consciousness and Anaesthesia
Ram Adapa
5. Mechanisms of Intravenous Anaesthetic Action
Hugh C. Hemmings Jr and Karl F. Herold
PART 2. PRINCIPLES OF PHARMACOLOGICAL MODELING
6. Basic Pharmacology: Kinetics and Dynamics for Dummies
Johan Raeder
7. Pharmacokinetic-Pharmacodynamic Modelling of Anesthetic Drugs
Johannes Hans Proost
8. Principles of Target Controlled Infusions
Steven L. Shafer
9. Performance of Target-Controlled Infusion Systems
Matthew TV Chan
10. How to Select a PK/PD Model
Kenichi Masui
PART 3. PHARMACOLOGY OF THE INTRAVENOUS ANESTHETIC AGENTS
11. Propofol PK-PD
Douglas J. Eleveld
12. Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions
Douglas E. Raines
13. Dexmedetomidine: The Science and Clinical Aspects in Adults and Children
Mohamed Mahmoud
14. Clinical Effects and Applications of Ketamine
Mark G. Roback
15. Neuromuscular Blocking Drugs: Pharmacology, Physiology and Clinical Aspects
Claude Meistelman
16. New and Upcoming Drugs: Intravenous Anesthetic AgentsJohn William Sear
17. Drug Interactions in Anesthesia
Jaap Vuyk
PART 4. PRACTICAL CONDUCT OF SEDATION AND ANESTHESIA
18. Pumps Pitfalls and Practicalities
Frank Engbers
19. EEG Monitoring of Depth of Anesthesia
Michael Sury
20. Monitoring the analgesic component of anesthesia
Isabelle Constant<
21. Intravenous Drugs for Sedation: Target Controlled, Patient Controlled, and Patient Maintained Delivery
Keith J Anderson and Gavin NC Kenny
22. Pediatric TIVA/TCI: Case Presentations and Discussion
Vivian Man-ying Yuen
23. TCI/TIVA Adult Case Studies
Nicholas Sutcliffe
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PART 5. SPECIAL POPULATIONS AND PROCEDURES
24. Intravenous Anesthesia in Obese Patients
Pablo Sepúlveda and Ignacio Cortínez
25. Pharmacokinetics and Dynamics on the Pediatric Population
Brian J. Anderson
26. Clinical Pharmacology of Intravenous Sedation in Children
Oliver Bagshaw
27. Sedation of the Critically Ill Child
Arno Brouwers, Sanne Vaassen, Gijs D Vos, Jan NM Schieveld, and Piet L Leroy
28. TCI & TIVA for Neurosurgery: Considerations and Techniqu
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