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Disordered Vertebral and Rib Morphology in Pudgy Mice: Structural Relationships to Human Congenital Scoliosis: 221 (Advances in Anatomy, Embryology and Cell Biology, 221) - Softcover

Book 161 of 173: Advances in Anatomy, Embryology and Cell Biology

Shapiro, Frederic

 
9783319431499: Disordered Vertebral and Rib Morphology in Pudgy Mice: Structural Relationships to Human Congenital Scoliosis: 221 (Advances in Anatomy, Embryology and Cell Biology, 221)
Softcover
ISBN 10: 3319431498 ISBN 13: 9783319431499
Publisher: Springer, 2016

Synopsis

​This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

"synopsis" may belong to another edition of this title.

About the Author

Frederic Shapiro received his MD degree from the University of Toronto Faculty of Medicine. He completed a residency in orthopedic surgery at the Montreal General Hospital: McGill University, Montreal, Quebec and a research fellowship in orthopedic surgery at Boston Children's Hospital.Frederic Shapiro, MD, Orthopedic Research Laboratory, Children's Hospital, Boston, USA.

From the Back Cover

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

"About this title" may belong to another edition of this title.

Publisher
Springer
Publication date
2016
Language
English
ISBN 10 
3319431498
ISBN 13 
9783319431499
Binding
Paperback
Number of pages
132