Biomolecular Interfaces: Interactions, Functions and Drug Design - Softcover

Fernández Stigliano, Ariel

Softcover

ISBN 10: 3319368141 ISBN 13: 9783319368146

Publisher: Springer, 2016

Synopsis

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.

The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

About this title

About the Author

The author is Ariel Fernandez Stigliano, who is an Argentinian–American theoretical chemist and mathematician, and heads his own pharmaceutical consultancy, Ariel Fernandez Innovation, at the Argentine National Scientific and Technical Research Council (CONICET) and at Collegium Basilea, the Institute of Advanced Study in Basel, Switzerland. Addresses: Avenida del Libertador 1092 – Piso 1 Buenos Aires 1112, Argentina 1419 Montrose Blvd. #305 Houston, TX 77019, USA Current Positions: * Senior Investigator, Argentine National Research Council (CONICET) (2011-). Instituto Argentino de Matemática, “Alberto P. Calderón", 1083 Buenos Aires, Argentina * Honorary Investigator, Collegium Basilea, Institute of Advanced Study, CH 4053 Basel, Switzerland (2006-) * Visiting Professor, National Tsing-Hua University, Hsinchu, Republic of China (2010-) · President, AF Innovation, SRL, a Pharmaceutical Consultancy (2010-). * Vice president and Chief Scientific Officer at Ariel Fernandez Consultancy,GmbH, a Biotechnology firm specialized in dynamic molecular design (2013-)

From the Back Cover

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.

The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Edition details

• Publisher: Springer
• Publication date: 2016
• Language: English
• ISBN 10: 3319368141
• ISBN 13: 9783319368146
• Binding: Paperback
• Number of pages: 391