Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring - Softcover

Softcover

ISBN 10: 3211822739 ISBN 13: 9783211822739

Publisher: Springer, 1991

Synopsis

There is increasing evidence for the clinicial value of the apo­ lipoprotein measurements. Besides cholesterol in plasma and li­ poprotein fractions, which is currently used as an indicator of cardiovascular risk, the measurement of the AI and B apolipopro­ teins can provide additional information about the patients' clinical status. Several studies show that apo B is higher and apo AI is lower in patients with angiographically documented coronary heart dis­ ease than in symptomatic patients without coronary heart disease. Moreover, discriminant analysis indicated that the concentration of Apo AI and B in plasma are better discriminators than lipo­ protein cholesterol for identifying patients with coronary heart disease. In some studies the apo Bjapo AI ratio appears to be a more powerful predictor than individual lipoproteins. In a recent study carried out in men, apolipoproteins AI and B were better correlated with the severity of cardiovascular disease than HDL and LDL cholesterol. The predictive power of apolipoproteins could however not be demonstrated in all studies and the value of apolipoprotein measurements in the field of clinical chemistry is still controversial. This is probably due to discrepancies between the results of various studies, arising from differences in the type of immunoassays, the lack of universal reference materials, differ­ ences between study protocols, variations in the selection of patients and in the grading and interpretation of coronary lesions.

About this title

Synopsis

This book describes the applications of the quantification of the plasma apo AI and B proteins for the identification and follow-up of patients at risk of developing cardiovascular disease. It begins with a few general papers about the biochemistry and pathophysiology of apolipoproteins, their methods and measurements. A review of the clinical studies where apoprotein measurements were performed for the evaluation of cardiovascular risk is included. Additional technical papers describe the use of immunoprecipitation methods and their application to the quantification of apo AI and B. The interpretation of these measurements by clinical chemists and their interpretation in combination with classical lipid parameters is analyzed at the end of the book.

Edition details

• Publisher: Springer
• Publication date: 1991
• Language: English
• ISBN 10: 3211822739
• ISBN 13: 9783211822739
• Binding: Paperback
• Number of pages: 112
• Editor: Rosseneu Maryvonne, Widhalm Kurt, Jarausch Jochen