Frontiers in Biotransformation: Volume 9: Regulation and Control of Complex Biological Processes by Biotransformation Frontiers in Biotransformation: Vol 9 - Hardcover

Ruckpaul, K

Hardcover

ISBN 10: 3055013670 ISBN 13: 9783055013676

Publisher: Wiley VCH, 1994

Synopsis

Volume 9 continues the series "Frontiers in Biotransformation" with the intention to elucidate the transfer of molecular data of biotransformation to its application in molecular medicine. The scope of the 7 chapters spans from the isolation and transfer of genes into other species as models for studying the molecular origin of certain diseases till to the investigation of the molecular mechanism of induction by analysing the regulation of genes whose expressed proteins control the metabolism of drugs and their elimination. The knowledge of these processes is of multiple importance for a medicinal application. The heterologous transfer of the renin gene does not only enable insight into the molecular basis of the development of hypertension but also opens possibilities for an early diagnosis of this disease and for designing targeted drugs. This is also true concerning the investigation of mechanisms of induction which on the one hand is aimed at detecting the molecular reason of drug resistance in chemotherapy and on the other hand leads to a specific regulation of gene activity. These and other aspects of the gene as subject of investigation are discussed by experts active in the field. This volume may be of interest for clinicians and bioscientists working in research laboratories and in hospitals likewise.

About this title

About the Author

Editors′ affiliations:
Klaus Ruckpaul, born in 1930, and Horst Rein, born in 1932, are professors at the Max Delbrueck Centre for Molecular Medicine in Berlin–Buch. Their field of activity covers studies on enzymes involved in the biotransformation of hormones, medicinal products and
in the activation of environmental toxins.

Edition details

• Publisher: Wiley VCH
• Publication date: 1994
• Language: English
• ISBN 10: 3055013670
• ISBN 13: 9783055013676
• Binding: Hardcover
• Number of pages: 263