Untranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression (SpringerBriefs in Biochemistry and Molecular Biology) - Softcover

Barrett, Lucy W.; Fletcher, Sue; Wilton, Steve D.

Softcover

ISBN 10: 3034806787 ISBN 13: 9783034806787

Publisher: Springer, 2013

Synopsis

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Edition details

• Publisher: Springer
• Publication date: 2013
• Language: English
• ISBN 10: 3034806787
• ISBN 13: 9783034806787
• Binding: Paperback
• Number of pages: 64