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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses) - Softcover
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Synopsis
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins.
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XXXIX, 151 p. Softcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Springer Theses. Recognizing Outstanding Ph.D. Research. Sprache: Englisch. Seller Inventory # 9516GB
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (eng)
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Springer International Publishing Dez 2019, 2019
ISBN 10: 3030131505
ISBN 13: 9783030131500
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling. 192 pp. Englisch. Seller Inventory # 9783030131500
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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ISBN 10: 3030131505
ISBN 13: 9783030131500
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil Presents an innovative approach, using gold chemistry to target zinc finger proteinsExplores the use of Travelling-Wave Ion Mobility coupled with Mas. Seller Inventory # 337743312
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses)
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling. Seller Inventory # 9783030131500
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Gold I, III Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Paperback. Condition: Brand New. reprint edition. 192 pages. 9.25x6.10x0.46 inches. In Stock. Seller Inventory # x-3030131505
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Taschenbuch. Condition: Neu. Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins | Raphael Enoque Ferraz de Paiva | Taschenbuch | Springer Theses | xxxix | Englisch | 2019 | Springer | EAN 9783030131500 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. Seller Inventory # 117451505
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Springer, Birkhäuser Dez 2019, 2019
ISBN 10: 3030131505
ISBN 13: 9783030131500
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C¿S coupling.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 192 pp. Englisch. Seller Inventory # 9783030131500
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses)
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