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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses) - Hardcover
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Synopsis
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
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From the Back Cover
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (eng)
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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ISBN 10: 3030008525
ISBN 13: 9783030008529
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling. 192 pp. Englisch. Seller Inventory # 9783030008529
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses)
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Goldi Iii Complexes Designed For Sele
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Gold(I,III) complexes designed for selective targeting and inhibition of zinc finger proteins
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Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil Presents an innovative approach, using gold chemistry to target zinc finger proteinsExplores the use of Travelling-Wave Ion Mobility coupled with Mas. Seller Inventory # 239348416
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling. Seller Inventory # 9783030008529
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C¿S coupling.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 192 pp. Englisch. Seller Inventory # 9783030008529
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Goldi Iii Complexes Designed For Sele
Published by
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ISBN 10: 3030008525
ISBN 13: 9783030008529
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