NF-kB, A Network Hub Controlling Immunity, Inflammation, and Cancer - Softcover

Michael Karin

Softcover

ISBN 10: 1936113554 ISBN 13: 9781936113552

Publisher: Cold Spring Harbor Press, 2011

Synopsis

NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-kB, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.

Edition details

• Publisher: Cold Spring Harbor Press
• Publication date: 2011
• Language: English
• ISBN 10: 1936113554
• ISBN 13: 9781936113552
• Binding: Paperback
• Edition number: 1
• Number of pages: 300
• Editor: Michael Karin