Hepatitis C: Antiviral Drug Discovery and Development - Hardcover

Hardcover

ISBN 10: 1904455786 ISBN 13: 9781904455783

Publisher: Caister Academic Press, 2011

Synopsis

The hepatitis C virus (HCV) is a significant public health problem of international importance. HCV is capable of establishing chronic infections resulting in progressive liver damage and other problems. Current drug therapies are ineffective, highlighting the need for better antiviral drugs. Recent research in HCV genetics and molecular biology have led to significant advances in our understanding of the life cycle of this important pathogen and may ultimately lead to better antiviral strategies. The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research, with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics include: the HCV life cycle * HCV assays * HCV resources * HCV databases * HCV infection systems * models of hepatitis C infections * overview of the drug pipeline * clinical trial design * clinical virology and drug development * NS3 protease inhibitors * NS3-NS4A complex inhibitors * NS3 helicase inhibitors * NS4B targets and inhibitors * NS5A inhibitors * nucleoside inhibitors * NS5B polymerase inhibitors * glycoprotein-dependent entry * host cell targets and inhibitors * innate immunity for HCV antiviral therapy.

About this title

Review

In the vast field of the publications on hepatitis C, a book like this is sorely needed. The authors have succeeded in writing a meaningful, user-friendly guide to hepatitis C... The book covers may subjects, from basic virology, epidemiology, and diagnostic testing to treatment and dealing with side effects of the antiviral drugs. The information is condensed but well organized, so readers are not overwhelmed. (Cezarina Mindru for Doody's, July 2013)

About the Author

Donald Jensen is the Director of the Center for Liver Disease, and is a Professor of Medicine at the University of Chicago Medical Center, Chicago, IL Nancy Reau is an Associate Professor of Medicine at the Center for Liver Disease, University of Chicago Medical Center, Chicago, IL

Edition details

• Publisher: Caister Academic Press
• Publication date: 2011
• Language: English
• ISBN 10: 1904455786
• ISBN 13: 9781904455783
• Binding: Hardcover
• Number of pages: 408
• Editor: Tan Seng-Lai, He Yupeng