An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases - Hardcover

Pasternak, Jack J.

Hardcover

ISBN 10: 1891786032 ISBN 13: 9781891786037

Publisher: John Wiley & Sons, 1999

Synopsis

This extensive publication provides coverage of the genetic principles governing human inherited diseases. More than a catalogue of disease related genes, this text explains the interaction of genes and their products and the consequences of these mechanisms in disease states in major organ systems such as muscle, the nervous system, and the eye, as well as cancer and mitochondrial disorders. In addition, coverage of some basic biology and physiology of each system is included to provide broader context for the study of disease.

About this title

About the Author

Jack J. Pasternak, Ph.D., is Professor of Biology at the University of Waterloo, Ontario, Canada. He received his doctoral degree from Indiana University and has taught a Human Molecular Genetics course to undergraduates and graduate students since 1986. Dr. Pasternak is the co–author (with his collegue Bernard R. Glick, Ph.D.) of the widely used text, Molecular Biotechnology: Principles and Applications of Recombinant DNA, 2nd Ed. (ASM Press, 1998).

From the Back Cover

With the explosion of new information from the Human Genome Project and new disease genes being identified at an extraordinary rate by laboratories around the world, the need for a scientifically sound and pedagogically refined text in Human Molecular Genetics has grown. This new text offers students and readers an extensive, up–to–date treatment of the genetic principles and fundamental molecular mechanisms that govern human inherited diseases. More than a catalogue of disease–related genes, this new text explains the interaction of genes and their products; the consequences of these mechanisms on disease states in major organ systems such as muscle, the nervous system, and the eyes; and cancer and mitochondrial disorders.

Praised by numerous reviewers for its timeliness and accuracy, An Introduction to Human Molecular Genetics is an ideal text for advanced undergraduate, early graduate, and basic medical school courses in human genetics. The book′s lucid style and compelling coverage make it essential reading for all those who seek a better understanding of the fast moving field of Human Molecular Genetics.

From the Pre–publication Reviews
"A very well written and highly–detailed treatment of a very important area in genetics. It is very different from the traditional human genetics text, which is part of its appeal. The organization is prefect. The basic science chapters are gems, and the transition to inherited diseases of selected systems provides excellent flexibility. It would be easy to teach a course to advanced undergraduate, beginning graduate, and/or medical students using this new text." —Edward M. Berger, Dartmouth College

"I found it impressive how up–to–date the material is. It is current and at the right level for medical students, advanced undergraduates, and beginning graduate students." —John Hardy, Mayo Clinic

"Chapter one was beautifully written and quite informative. Chapter eight provides a really nice overview of the muscular dystrophies." —Louis Kunkel, Harvard Medical School, Howard Hughes Medical Institute

Edition details

• Publisher: John Wiley & Sons
• Publication date: 1999
• Language: English
• ISBN 10: 1891786032
• ISBN 13: 9781891786037
• Binding: Hardcover
• Number of pages: 516