Phagocyte Production and Function Following Burn Injury (Medical Intelligence Unit) - Hardcover

Peterson, Verlyn M., M.D.; Ambruso, Daniel R., M.D.

Hardcover

ISBN 10: 1879702576 ISBN 13: 9781879702578

Publisher: R G Landes Co, 1994

Synopsis

An overview of the past work, current dilemmas, and future directions of clinical and basic research in the areas of postburn myelopoiesis and neutrophil physiology. It presents the bone marrow-bone marrow stroma and its circulating progeny as an integrated organ system that is regulated by a series of stimulatory and inhibitory cytokines and is prone to failure after severe burns, trauma, or sepsis. At the cellular level it describes the molecular and biochemical events that define both normal and abnormal neutrophil function. Model systems of postburn myelopoiesis and neutrophil function are developed in order to create logical, mechanistic ways of thinking about the production and function of neutrophils after burn injury. Annotation copyright Book News, Inc. Portland, Or.

About this title

Synopsis

This book discusses up-to-date information on haematopoietic growth factors that regulate the production and function of phagocytes under normal, steady-state conditions. It summarizes alterations in myelopoiesis and mature phagocyte function that accompany major thermal injuries. It places special emphasis on in vitro model systems that can be used to determine the probable causes and possible treatments for post-burn related defects in the proliferation and maturation of myeloid progenitors and the function of their mature progeny. Exploration of the potential use of recombinant human cytokines as biological response modifiers in immunosuppressed burn patients is discussed.

Edition details

• Publisher: R G Landes Co
• Publication date: 1994
• Language: English
• ISBN 10: 1879702576
• ISBN 13: 9781879702578
• Binding: Hardcover