This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.
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This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management of MS. The fourth edition has been extensively revised and features more than 50% new material.
Jeffrey A. Cohen MD is Director of the Experimental Therapeutics Program at the Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
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