Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics: Volume 42 (Drug Discovery Series) - Hardcover

Hardcover

ISBN 10: 1849736634 ISBN 13: 9781849736633

Publisher: Royal Society of Chemistry, 2015

Synopsis

An exciting volume that provides a comprehensive and up-to-date review on the potential of peptides and proteins from animal venoms as human therapeutics.

About this title

About the Author

Professor Glenn King has been working on animal venoms since 1996.He has extensive experience in the discovery, production, and structural and functional characterization of venom proteins, and is intimately aware of the issues surrounding their development as drugs and insecticides. In 2006,Professor King founded an agricultural biotechnology company, Vestaron Corporation, that is developing spider-venom peptides discovered in the lab as bioinsecticides.His current research is largely focussed on the development of venom peptides as analgesics for the treatment of chronic pain.

From the Back Cover

The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

Excerpt. © Reprinted by permission. All rights reserved.

Venoms to Drugs

Venom as a Source for the Development of Human Therapeutics

By Glenn F. King

The Royal Society of Chemistry

Copyright © 2015 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-84973-663-3

Contents

Chapter 1 Seeing the Woods for the Trees: Understanding Venom Evolution as a Guide for Biodiscovery Bryan G. Fry, Ivan Koludarov, Timothy N. W. Jackson, Mandë Holford, Yves Terrat, Nicholas R. Casewell, Eivind A. B. Undheim, Irina Vetter, Syed A. Ali, Dolyce H. W. Low, and Kartik Sunagar, 
Chapter 2 The Structural Universe of Disulfide-Rich Venom Peptides Vincent Lavergne, Paul F. Alewood, Mehdi Mobli, and Glenn F. King, 
Chapter 3 Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches Sébastien Dutertre, Eivind A. B. Undheim, Sandy S. Pineda, Ai-Hua Jin, Vincent Lavergne, Bryan G. Fry, Richard J. Lewis, Paul F. Alewood, and Glenn F. King, 
Chapter 4 Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification Irina Vetter, Wayne C. Hodgson, David J. Adams, and Peter McIntyre, 
Chapter 5 Reptile Venoms as a Platform for Drug Development Ryan J. R. McCleary, Tse S. Kang, and R. Manjunatha Kini, 
Chapter 6 The Molecular Diversity of Conoidean Venom Peptides and their Targets: From Basic Research to Therapeutic Applications Russell W. Teichert, Baldomero M. Olivera, J. Michael McIntosh, Grzegorz Bulaj, and Martin P. Horvath, 
Chapter 7 Scorpion Venoms as a Platform for Drug Development Ricardo C. Rodríguez de la Vega, Gerardo Corzo, and Lourival D. Possani, 
Chapter 8 Therapeutic Applications of Spider-Venom Peptides Jennifer J. Smith, Carus Ho Yee Lau, Volker Herzig, Maria P. Ikonomopoulou, Lachlan D. Rash, and Glenn F. King, 
Chapter 9 Case Study 1: Development of the Analgesic Drugs Prialt® and Xen2174 from Cone Snail Venoms Richard J. Lewis, 
Chapter 10 Case Study 2: Transforming a Toxin into a Therapeutic: the Sea Anemone Potassium Channel Blocker ShK Toxin for Treatment of Autoimmune Diseases Raymond S. Norton, Michael W. Pennington, and Christine Beeton, 
Chapter 11 Engineering Venom Peptides to Improve Their Stability and Bioavailability Muharrem Akcan and David Craik, 
Chapter 12 Manufacturing of Venom-Derived Therapeutic Peptides Oleg Werbitzky and Matthieu Giraud, 
Subject Index, 

CHAPTER 1

Seeing the Woods for the Trees: Understanding Venom Evolution as a Guide for Biodiscovery

BRYAN G. FRY, IVAN KOLUDAROV, TIMOTHY N. W. JACKSON, MANDË HOLFORD, YVES TERRAT, NICHOLAS R. CASEWELL, EIVIND A. B. UNDHEIM, IRINA VETTER, SYED A. ALI, DOLYCE H. W. LOW, AND KARTIK SUNAGAR

1.1 The Fundamental Problems

The majority of commercial drugs being used today in both developed and developing countries are based on natural products. Most of these products are based upon plants, but research into animal venoms holds great potential for the discovery of novel medicinally useful natural products. Knowledge of the evolutionary origins of venom proteins/peptides and the forces shaping the biodiversity seen today is crucial for efficient biodiscovery. In addition, efficient utilisation of venom toxins in drug design and development cannot be achieved without recognition of the true biochemical, ecological, morphological, and pharmacological diversity of venoms and associated venom systems. A major limitation of the use of venom proteins thus far has been the very narrow taxonomical range studied. Entire groups of venomous animals remain virtually ignored. Those that have been examined have appa

Edition details

• Publisher: Royal Society of Chemistry
• Publication date: 2015
• Language: English
• ISBN 10: 1849736634
• ISBN 13: 9781849736633
• Binding: Hardcover
• Number of pages: 352
• Editor: Glenn F King