Photodynamic Inactivation of Microbial Pathogens: Medical and Environmental Applications: Volume 11 (Comprehensive Series in Photochemical & Photobiological Sciences) - Hardcover

Hardcover

ISBN 10: 1849731446 ISBN 13: 9781849731447

Publisher: Royal Society of Chemistry, 2011

Synopsis

The first book to comprehensively cover the use of light and photosensitising agents for controlling the population of microbial pathogens.

About this title

About the Author

Dr Michael R. Hamblin is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital and an Associate Professor of Dermatology at Harvard Medical School. He received his PhD in synthetic organic chemistry from Trent University in England. His interests lie in photodynamic therapy for infections, cancer, and heart disease and also in low-level light therapy for wound healing, arthritis, traumatic brain injury and hair regrowth. His research program is supported by NIH, CDMRP and CIMIT among others. He has published over 125 peer-reviewed articles, over 120 conference proceedings, book chapters and international abstracts, and holds 8 patents.

From the Back Cover

Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.

Excerpt. © Reprinted by permission. All rights reserved.

Photodynamic Inactivation of Microbial Pathogens: Medical and Environmental Applications

By Michael R. Hamblin, Giulio Jori

The Royal Society of Chemistry

Copyright © 2011 European Society for Photobiology
All rights reserved.

ISBN: 978-1-84973-144-7

Contents

Chapter 1 Antimicrobial Photodynamic Therapy: Basic Principles Giulio Jori, Monica Camerin, Marina Soncin, Laura Guidolin and Olimpia Coppellotti, 
Chapter 2 Phenothiazinium Salts as Antimicrobial Photosensitizing Agents Mark Wainwright, 
Chapter 3 Approaches to Kill Gram-negative Bacteria by Photosensitized Processes Yeshayahu Nitzan and Izabella Pechatnikov, 
Chapter 4 Innovative Design of Antimicrobial Photosensitizers Michael R. Hamblin, Sulbha K. Sharma and Gitika B. Kharkwal, 
Chapter 5 Porphyrins as Antimicrobial Photosensitizing Agents A. Almeida, A. Cunha, M. A. F. Faustino, A. C. Tomé and M. G. P. M. S. Neves, 
Chapter 6 Fullerene Derivatives as Antimicrobial Photosensitizing Agents M. Elisa Milanesio and Edgardo N. Durantini, 
Chapter 7 Photosensitizer Delivery for Photodynamic Antimicrobial Chemotherapy Ryan F. Donnelly, Corona M. Cassidy and Michael M. Tunney, 
Chapter 8 Photodynamic Therapy of Localized Infections in Animal Models Tianhong Dai and Michael R. Hamblin, 
Chapter 9 Pathogen Reduction in Blood for Transfusion Using Photodynamic Treatments Ehud Ben-Hur and Raymond P. Goodrich, 
Chapter 10 PDT for Acne Michael H. Gold, 
Chapter 11 PDT for Viral Lesions Michael H. Gold, 
Chapter 12 PDT For Cutaneous Leishmaniasis Oleg E. Akilov, Ulysses W. Sallum and Tayyaba Hasan, 
Chapter 13 Antimicrobial Photodynamic Therapy (aPDT) for Oral Infections Jonathan Pratten, Veronique Benhamou and Cale Street, 
Chapter 14 Photodynamic Antifungal Chemotherapy P. G. Calzavara-Pinton, M. T. Rossi and B. Ortel, 
Chapter 15 Photodynamic Therapy for Wound Infections Stanley B. Brown and Clare L. Conway, 
Chapter 16 Photodynamic Therapy for Helicobacter pylori Infections Javad T. Hashmi and Michael R. Hamblin, 
Chapter 17 Inactivation of Microbial Pathogens by Photosensitized Processes: Environmental Applications Michela Magaraggia, Olimpia Coppellotti, Clara Fabris, Laura Guidolin and Giulio Jori, 
Subject Index, 

CHAPTER 1

Antimicrobial Photodynamic Therapy: Basic Principles

Giulio Jori, Monica Camerin, Marina Soncin, Laura Guidolin and Olimpia Coppellotti

Department of Biology, University of Padova, Via Ugo Bassi 58B, 35131 Padova, Italy

Table of Contents

1.1. Introduction

1.2. Photosensitized Inactivation of Microbial Cells: General Aspects

1.2.1. The Target

1.2.2. Photobiological Processes in the Photosensitized Inactivation of Microbial Cells

1.2.3. The Photosensitizer

1.3. Kinetics and Mechanism of the Photosensitized Inactivation of Microbial Cells

1.4. Conclusions

References

1.1. Introduction

Photodynamic therapy (PDT) represents a well-established modality for the treatment of a variety of malignant tumours; on the other hand, this technique is presently being extended to several non-cancerous conditions, especially those which are characterized by overgrowth of unwanted or abnormal cells, such as inter alia several dermatological diseases, benign prostatic hyperplasia and age-related macular degeneration. An increasing amount of attention is also being focused on the application of PDT for the treatment of infectious diseases. In actual fact, the possibility to kill microorganisms by the combined action of visible light and a photosensitizing dye wa

Edition details

• Publisher: Royal Society of Chemistry
• Publication date: 2011
• Language: English
• ISBN 10: 1849731446
• ISBN 13: 9781849731447
• Binding: Hardcover
• Number of pages: 434
• Editor: Michael R Hamblin