Tissue engineering is rapidly developing as a technique for the repair and regeneration of diseased tissue in the body. This authoritative and wide-ranging book reviews how ceramic and polymeric biomaterials are being used in tissue engineering. The first part of the book reviews the nature of ceramics and polymers as biomaterials together with techniques for using them such as building tissue scaffolds, transplantation techniques, surface modification and ways of combining tissue engineering with drug delivery and biosensor systems. The second part of the book discusses the regeneration of particular types of tissue from bone, cardiac and intervertebral disc tissue to skin, liver, kidney and lung tissue.
Key Features: an innovative and up-to-date reference for professionals and academics; environmental scanning electron microscopy is discussed; analyses bone regeneration and specific types of tisue engineering; written by distinguished editors at the forefront of the industry.
Contents: Part 1 General issues: Ceramic biomaterials; Polymeric biomaterials; Bioactive ceramics and glasses; Biodegradable and bioactive polymer/ceramic composite scaffolds; Transplantation of engineered cells and tissues; Surface modification to tailor the biological response; Combined tissue engineering and drug delivery; Carrier systems and biosensors for biomedical applications; Characterisation using x-ray photoelectron spectroscopy (XPS) and secondary ion spectrometry (SIMS); Characterisation using environmental scanning electron microscopy (ESEM); Characterisation of cells on tissue engineered construsts using imaging techniques/microscopy; Characterisation using Raman micro-spectroscopy. Part 2 Tissue and organ generation: Engineering of tissues and organs; Bone regeneration and repair using tissue engineering; Bone tissue engineering and biomineralisation; Cardiac tissue engineering; Intervertebral disc tissue engineering; Skin tissue engineering; Liver tissue engineering; Kidney tissue engineering; Bladder tissue engineering; Nerve bioengineering; Lung tissue engineering; Intestine tissue engineering; Micromechanics of hydroxyapatite-based biomaterials and tissue engineering scaffolds; Cartilage tissue engineering.
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Dr Aldo R Boccaccini is a Reader in Materials Science at Imperial College London, UK. Dr Boccaccini has published extensively in the area of scaffold materials and composites. Dr Julie E Gough is a Senior Lecturer in Biomedical Materials at the University of Manchester, UK. Dr Gough is widely respected for her research and activities in the field of biomaterials and tissue engineering.
Research and developments in tissue engineering have led to strong growth in this area. An important part of this is the progress in the applications of biomaterials in tissue engineering, making it an area of great interest in the scientific community. This second edition is a comprehensive review of the advances in the uses of ceramics and polymers in this field.
Part I considers the biomaterials used for tissue engineering. It introduces the properties and processing of bioactive ceramics and glasses as well as polymeric biomaterials, particularly biodegradable polymer phase nanocomposites. Part II reviews the advances in techniques for processing, characterisation and modelling of materials. The topics covered range from nanoscale design in biomineralization for bone tissue engineering to microscopy techniques for characterising cells to materials for perfusion bioreactors. Further, carrier systems and biosensors in biomedical applications are considered. Finally, Part III looks at the specific types of tissue and organ regeneration, with chapters concerning kidney, bladder, peripheral nerve, small intestine, skeletal muscle, cartilage, liver and myocardial tissue engineering. Important developments in collagen-based tubular constructs, bioceramic nanoparticles and multifunctional scaffolds for tissue engineering and drug delivery are also explained.
Tissue engineering using ceramics and polymers is a valuable reference tool for both academic researchers and scientists involved in biological materials or tissue engineering, including in the areas of bone reconstruction and repair, orthopaedic surgery and soft-tissue surgery.
Professor Aldo R. Boccaccini is Professor of Biomaterials and head of the Institute of Biomaterials at the University of Erlangen, Germany. Professor Peter X. Ma is the Richard H Kingery Endowed Collegiate Professor at the University of Michigan, USA
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