Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities - Hardcover

Deberardinis, Ralph J; Vousden, Karen; Chandel, Navdeep

Hardcover

ISBN 10: 1621824705 ISBN 13: 9781621824701

Publisher: Cold Spring Harbor Laboratory Press, 2024

Synopsis

Cancer cells often display metabolic changes that distinguish them from normal cells in the body. Their preference for glycolysis over aerobic respiration even in the presence of oxygen was first observed over a century ago; however, it is only over the past two decades that researchers have begun to characterize all the pathways involved and investigate the therapeutic possibilities. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of the diversity of metabolic changes seen in cancer cells and their roles in sustaining tumor survival and proliferation. The contributors cover the new technologies being used to monitor metabolism in cells, the Warburg effect and the importance of mitochondria, metabolic signaling, and the importance of redox reactions and antioxidants. Other chapters examine the role of the tumor microenvironment, metal ions, and the immune system. The book also discusses the role of diet and how studies of patients are revealing how metabolic reprogramming occurs. It will thus be of interest not only to biochemists and oncologists but to all biologists interested in how the behavior of cells is regulated and coordinated.

Edition details

• Publisher: Cold Spring Harbor Laboratory Press
• Publication date: 2024
• Language: English
• ISBN 10: 1621824705
• ISBN 13: 9781621824701
• Binding: Hardcover
• Number of pages: 438