Synopsis
"PTEN is an important cellular enzyme that is frequently mutated in cancer. In normal cells, it downregulates signaling through the PI3-kinase pathway that controls cell proliferation. When PTEN is mutated, the PI3 pathway becomes overactive, which can contribute to cancer. This volume examines advances in our understanding of the functions of the PTEN protein, its regulation, and how loss of PTEN can promote the development and progression of different cancers"--
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PTEN Family
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The Pten Family
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The PTEN Family (Perspectives CSHL)
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