Impedimetric Biosensors for Medical Applications (UK PROFESSIONAL SCIENCE & TECHNOLOGY Technical) - Hardcover

Jo V. Rushworth (author); Natalie A. Hirst (author); Jack A. Goode (author); Douglas J. Pike (author); Asif Ahmed (author) & Paul A. Millner (author)

Hardcover

ISBN 10: 1606506366 ISBN 13: 9781606506363

Publisher: Momentum Press, 2013

Synopsis

In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer-by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalization and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph describes case studies of successful impedance-based biosensors for the detection of a range of analytes from small molecules up to whole microorganisms. Finally, the authors put forward future perspectives for the clinical applications of impedimetric biosensors.

About this title

About the Author

Jo Rushworth received her BSc in Biochemistry in 2005 and her Wellcome Trust-funded PhD in 2012 from the University of Leeds. Jo also carried out research projectsat the Sainsbury Laboratory (Norwich, UK) and the Université deParis-Sud (France). In between her degree and PhD, Jo was a high-school Chemistry teacher. Jo studied the molecular and structural biology of amyloid-beta oligomers, a causative agent of Alzheimer's disease, during herPhD. She is now integrating her Alzheimer's research background with herinterest in electrochemical biosensors to develop impedimetric sensors forthe specific detection of biologically-relevant amyloid-beta oligomers.

Natalie Hirst gained a BSc in Experimental Pathology in 2005, before a Medicaldegree in 2006 from the University of London, Barts and the LondonSchool of Medicine and Dentistry. She is a member of the Royal Collegeof Surgeons of England, having passed the requisite examination. She iscurrently in her final year of study for a PhD with the Bionanotechnology Group at the University of Leeds, having taken time out of full time surgicaltraining. Her current research is the development of electrochemical biosensorsfor early detection of complications after bowel surgery.

Edition details

• Publisher: Momentum Press
• Publication date: 2013
• Language: English
• ISBN 10: 1606506366
• ISBN 13: 9781606506363
• Binding: Hardcover
• Number of pages: 78