Animal Models of Epilepsy: Methods and Innovations: 40 (Neuromethods, 40) - Hardcover

Hardcover

ISBN 10: 1603272623 ISBN 13: 9781603272629

Publisher: Humana, 2009

Synopsis

Epilepsy is fairly unique among the various neurological disorders as it provides the neuroscientist with almost boundless opportunities to examine basic neurobiological mechanisms. Not surprisingly, advances in epilepsy research are closely tied to dev- opment of innovative neurobiological methodologies. In many cases the practical application of these innovations - especially in the context of a neurological disorder with anatomical, molecular, electrophysiological, and behavioral components such as epilepsy - can be found in the development of new animal models. In turn, our understanding of the pathogenesis of epilepsy (and new therapy development) greatly benefits from these models. Taking advantage of transgenic and homologous rec- binationtechniques,laboratorieshave recentlymovedbeyondthestandardconvulsant or stimulation models in rat to develop novel mouse models of epilepsy. This forward thinking approach has recently been applied to genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles), and Danio rerio (zebrafish). With contributions from prominent investigators in this field, this book provides a reviewoftheseemerginganimalmodelsofepilepsy. Priortextbooksdevotedtomodels of seizure and epilepsy almost exclusively categorized rat models with little attention paid to these more innovative approaches. Here we attempt to diverge from the conventionalepilepsyliteratureandfocusonanimalmodelsthatattempttoincorporate the latest technological advancements in neurobiology. While some of these models andapproaches are,admittedly, at veryearly stages ofdevelopment andmay ultimately fall short of widespread utilization, it is through the consideration and presentation of these models that the authors' hope to advance and challenge the field of epilepsy research.

About this title

From the Back Cover

With its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods™ series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field.

Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

Edition details

• Publisher: Humana
• Publication date: 2009
• Language: English
• ISBN 10: 1603272623
• ISBN 13: 9781603272629
• Binding: Hardcover
• Number of pages: 289
• Editor: Baraban Scott C.