Target Discovery and Validation Reviews and Protocols: Emerging Molecular Targets and Treatment Options,Volume 2: 361 (Methods in Molecular Biology, 361) - Hardcover

Hardcover

ISBN 10: 1588298906 ISBN 13: 9781588298904

Publisher: Humana, 2007

Synopsis

Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.

Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.

Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.

Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.

About this title

Review

From the reviews:

"...provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical applications." -Anticancer Research

"Review current methods for drug target discovery and validation. ... the chapters are generally well written and clear, and provide extensive references to the current literature. Overall ... provide useful overviews that would provide entry into this field. Novice and more experienced researchers ... would find useful information ... ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)

Synopsis

The aim of "Target Discovery and Validation" is to discuss the recent progress in our understanding of the molecular mechanisms of most human diseases and technical advances in target identification and validation. The covered topics include cancers, autoimmune diseases, cell signaling, gene profiling technologies, tumor immunology, tumor editing, immune tolerance and transgenic animals.

Edition details

• Publisher: Humana
• Publication date: 2007
• Language: English
• ISBN 10: 1588298906
• ISBN 13: 9781588298904
• Binding: Hardcover
• Number of pages: 359
• Editor: Sioud Mouldy