Cardiovascular Proteomics: Methods and Protocols: 357 (Methods in Molecular Biology, 357) - Hardcover

Hardcover

ISBN 10: 1588295354 ISBN 13: 9781588295354

Publisher: Humana, 2007

Synopsis

Over the past few years, the power and potential of proteomics has become widely recognized. The use of proteomics for the study of complex diseases is increasing and is particularly applicable to cardiovascular disease, the leading cause of death in developed countries. The ability to investigate the complete proteome provides a critical tool toward elucidating the complex and multif- torial basis of cardiovascular biology, especially disease processes. Proteomics involves the integration of a number of technologies with the aim of analyzing all the proteins expressed by a biological system in response to various stimuli under different pathophysiological conditions. The proteomic approach offers the ability to evaluate simultaneously the changes in protein expression and cell signaling pathways in response to such conditions as atherosclerosis, c- diac hypertrophy, stroke, or heart failure. Cardiovascular Proteomics: Methods and Protocols covers many of the above aspects of the proteomic approach in the cardiovascular field. This v- ume takes the reader through the complete process of proteomic analysis, from the obtention of specific heart proteins (troponin I) to the new techniques of identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, or the application of phage display techniques to decipher the molecular diversity of blood vessels.

About this title

Review

"...a fine collection of methods and protocols currently employed in cardiovascular proteomics that will be of great use to all who are invovled in cardiovascular research." -Proteomics Clin. Appl.

"...a thorough set of protocols for the cardiac biology community.  Most laboratories will have some of these in place, but can profit from the broad coverage of this book." -Doody's Book Review, Weighted Numerical Score: 76 - 3 stars

Synopsis

"Cardiovascular Proteomics: Methods and Protocols" covers many of the aspects of the proteomic approach in the cardiovascular field. This volume takes the reader through the complete process of proteomic analysis, from the obtention of specific heart proteins (troponin I) to the new techniques of identifying risk biomarkers of atherome plaque rupture analyzing the secretome of explanted endartrectomies cultured in vitro or the application of phage display techniques to decipher the molecular diversity of blood vessels.

Edition details

• Publisher: Humana
• Publication date: 2007
• Language: English
• ISBN 10: 1588295354
• ISBN 13: 9781588295354
• Binding: Hardcover
• Number of pages: 432
• Editor: Vivanco Fernando