This text combines the basic principles and theories of transport in biological systems with fundamental bioengineering. It contains real world applications in drug delivery systems, tissue engineering, and artificial organs. Considerable significance is placed on developing a quantitative understanding of the underlying physical, chemical, and biological phenomena. Therefore, many mathematical methods are developed using compartmental approaches. The book is replete with examples and problems.
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Basic Transport Phenomena in Biomedical Engineering, Second Edition fuses fundamental engineering and life science principles to uncover key concepts in biomedical engineering transport phenomena. Coverage begins with basic thermodynamic properties, body fluids, solute diffusion and transport, physical and flow properties of fluids and blood, tissue oxygen transport, and pharmacokinetics. These topics are updated to include new material on fluid mechanics, diffusion, and mass transfer in boundary layers. Building upon this foundation, the book describes the application of these principles to the development and design of drug delivery systems, artificial organs, bioartificial organs, and tissue engineering. Also new to this edition are an introductory chapter on units and dimensions, including tips for solving engineering problems and a discussion of material balances, and a chapter reviewing thermodynamic concepts with emphasis on solutions.
Considerable importance is placed on developing a quantitative understanding of the underlying physical, chemical, and biological phenomena. Mathematical models are developed from scratch using the conceptually simple "shell balance" or "compartmental" approaches to obtain the differential equations that describe a particular situation. Numerous examples throughout the book employ mathematical techniques and numerical methods. Where possible, the results obtained from them are compared with actual experimental data taken from the research literature.
Each chapter ends with problems designed to help students gain confidence in the development of mathematical models for a variety of problems of varying degrees of complexity. A brief discussion of these mathematical techniques and numerical methods are described in the book. These techniques and methods include similarity transforms, Laplace transforms, finding the root of a nonlinear equation, linear regression, nonlinear regression, and solving ordinary differential equations.
This updated edition is ideal for junior and senior undergraduates and first-year graduate students taking courses in biotransport phenomena. Students and professionals in bioengineering and biomedical engineering, as well as other disciplines, such as chemical and mechanical engineering, physiology, biophysics and cell biology will find this text a valuable resource. A solutions manual will be available to qualified instructors.
Ronald L. Fournier is a professor in the Department of Bioengineering at The University of Toledo. He is also the founding chair of the Department of Bioengineering. During his twenty years at Toledo, he has taught a variety of chemical engineering and bioengineering subjects to include courses in biochemical engineering, biomedical engineering transport phenomena, biomedical engineering design, and artificial organs. His research interests and scholarly publications are in the areas of bioartificial organs, tissue engineering, novel bioreactors, and pharmacokinetics.
Prof. Fournier is on the editorial review board of Technology and Healthcare in the International Journal of Health Care Engineering. He is a research journal reviewer for the following journals: AIChE Journal, Biotechnology and Bioengineering, Biomaterials, Cell Transplantation, Tissue Engineering, Industrial & Engineering Chemistry, and Enzyme & Microbial Technology. Prof. Fournier is a member of the American Institute of Chemical Engineers, American Diabetes Association, Juvenile Diabetes Foundation International, American Association for the Advancement of Science, American Chemical Society, Cell Transplantation Society, Biomedical Engineering Society, American Society of Engineering Education, and is a Fellow of the American Institute of Medical & Biological Engineering.
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