Advances in DNA Sequence-Specific Agents (Volume 2) - Hardcover

Hardcover

ISBN 10: 1559381663 ISBN 13: 9781559381666

Publisher: Elsevier Science, 1996

Synopsis

DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

Edition details

• Publisher: Elsevier Science
• Publication date: 1996
• Language: English
• ISBN 10: 1559381663
• ISBN 13: 9781559381666
• Binding: Hardcover
• Edition number: 1
• Number of pages: 256
• Editor: Chaires J.B.