Microdialysis in Drug Development: 4 (AAPS Advances in the Pharmaceutical Sciences Series, 4) - Softcover

Softcover

ISBN 10: 1489996214 ISBN 13: 9781489996213

Publisher: Springer, 2014

Synopsis

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.

About this title

About the Author

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.

From the Back Cover

In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.

Edition details

• Publisher: Springer
• Publication date: 2014
• Language: English
• ISBN 10: 1489996214
• ISBN 13: 9781489996213
• Binding: Paperback
• Number of pages: 352
• Editor: Müller Markus