Practical Process Research & Development - Softcover

Anderson, Neal G.

9781483299778: Practical Process Research & Development

Softcover

ISBN 10: 1483299775 ISBN 13: 9781483299778

Publisher: Academic Press, 2014

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, finechemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring keycompounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates areidentified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, andacademicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry" "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

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Review

"Neal Anderson has assembled an immense amount of practical information that is absolutely essential to the design and execution of safe, reliable, efficient large-scale syntheses. Critical facts once hidden in obscure sources or chemical folklore are now organized for ready access. Countless illustrative reactions and sequences from the latest literature are discussed lucidly, and impress upon the reader the scope and sophistication of modern organic process chemistry. This book is a must for beginners and old hands alike."
- Raymond Conrow, Assistant Technical Director, Chemical Preparations Research, Alcon Laboratories
"Perhaps the highest praise one can give this book is to say that the Foreword by Barry Sharpless raises very high expectations...and the book meets and at times exceeds those expectations."
- Organic Process Research & Development

From the Back Cover

Bringing a compound to market quickly and profitably requires efficient and
cost-effective processes for preparing large amounts of the target compound
and intermediates. The key to rapid and successful process development is avoiding scale-up problems. However, an understanding of scale-up issues is rarely
taught in academia and may take years of industrial experience to acquire.

Practical Process Research & Development teaches how to anticipate and
avoid these problems when processes are being scaled up from the research lab or
pilot plant. The approach is pragmatic, with a minimum of theory and over
100 practical scale-up tips. Many tables and detailed reaction schemes
allow the reader to identify critical processing steps quickly. This
practical guide is essential reading for chemists and chemical engineers
involved in industrial process research and/or process development and for
anyone seeking a clearer understanding of how and why process R&D is conducted in the pharmaceutical and fine chemicals industries.

KEY FEATURES

� Provides insights into generating rugged, practical, cost-effective
processes for the chemical preparation of "small molecules"
� Breaks down process optimization into route, reagent, and solvent
selection, development of reaction conditions, workup, crystallizations, and more
� Describes how to anticipate and avoid difficulties in scaling up reactions
� Discusses guidelines for the timely development of processes
� Illuminates principles with examples from the recent literature
� Includes over 100 tips for rapid process development
� Presents guidelines for implementing and troubleshooting processes
� Written by an author with over 22 years experience in process R&D in
the pharmaceutical industry

"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department."
--Sean T. Nugent, Searle Research & Development|Bringing a compound to market quickly and profitably requires efficient and
cost-effective processes for preparing large amounts of the target compound
and intermediates. The key to rapid and successful process development is avoiding scale-up problems. However, an understanding of scale-up issues is rarely
taught in academia and may take years of industrial experience to acquire.

Practical Process Research & Development teaches how to anticipate and
avoid these problems when processes are being scaled up from the research lab or
pilot plant. The approach is pragmatic, with a minimum of theory and over
100 practical scale-up tips. Many tables and detailed reaction schemes
allow the reader to identify critical processing steps quickly. This
practical guide is essential reading for chemists and chemical engineers
involved in industrial process research and/or process development and for
anyone seeking a clearer understanding of how and why process R&D is conducted in the pharmaceutical and fine chemicals industries.

KEY FEATURES

� Provides insights into generating rugged, practical, cost-effective
processes for the chemical preparation of "small molecules"
� Breaks down process optimization into route, reagent, and solvent
selection, development of reaction conditions, workup, crystallizations, and more
� Describes how to anticipate and avoid difficulties in scaling up reactions
� Discusses guidelines for the timely development of processes
� Illuminates principles with examples from the recent literature
� Includes over 100 tips for rapid process development
� Presents guidelines for implementing and troubleshooting processes
� Written by an author with over 22 years experience in process R&D in
the pharmaceutical industry

"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department."
--Sean T. Nugent, Searle Research & Development