Synopsis
Part I. Molecular Mechanisms in Rheumatic Diseases Genetics Peter K. Gregersen Viruses Andras Perl Apoptosis John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou Humoral Response Gary S. Gilkeson T-Cell Signaling Gary A. Koretzky and Erik J. Peterson Adhesion and Costimulatory Molecules Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler Transcription Factors Henry K. Wong Immune Complexes Mark H. Wener Complement V. Michael Holers Eicosanoids and Other Bioactive Lipids Leslie J. Crofford Collagens Sergio A. Jiménez Part II. Cellular Mechanisms in Rheumatic Diseases T-Lymphocytes Nilamadhab Mishra and Gary M. Kammer B-Lymphocytes Robert F. Ashman Monocytes and Macrophages James M. K. Chan and Sharon M. Wahl Polymorphonuclear Cells Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein Synoviocytes David E. Yocum Chondrocytes Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud Osteoblasts and Osteoclasts Stavros C. Manolagas Animal Models Thomas J. Lang and Charles S. Via Part III. Pathogenesis of Rheumatic Diseases Systemic Lupus Erythematosus Stamatis-Nick C. Liossis and George C. Tsokos Rheumatoid Arthritis Richard M. Pope and Harris Perlman Inflammatory Myopathies Norbert Goebels and Reinhard Hohlfeld Systemic Sclerosis Timothy M. Wright Vasculitis Jörg J. Goronzy and Cornelia M. Weyand Osteoarthritis Robin Poole and Ginette Webb Osteoporosis Stavros C. Manolagas Heritable Disorders of Connective Tissue Petros Tsipouras Part IV. Molecular Aspects of Treatment of RheumaticDiseases Corticosteroids Henry K. Wong and George C. Tsokos Cytotoxic Drugs David A. Fox and W. Joseph McCune Complement Inhibitors Savvas C. Makrides Cytokine Response Modifiers Richard E. Jones and Larry W. Moreland Restoration of Immune Tolerance Woodruff Emlen Metalloproteases and Their Modulation as Treatment in Osteoarthritis Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier Gene Therapy Robert P. Kimberly
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