Synopsis
Chemical Structure of Gangliosides.- Introductory Remarks on Chemical Structures of Gangliosides.- Ganglioside Designation.- A New Approach to the Analysis of Ganglioside Molecular Species.- Isolation and Separation of Gangliosides on a New Form of Glass Bead Ion Exchanger.- Structures of Some New Complex Gangliosides of Fish Brain.- Structural Fingerprinting of Gangliosides and Other Glycoconjugates by Mass Spectrometry.- Mass Spectra and NMR Spectra of Gangliosides Containing Fucose.- Trifluoroacetolysis, a New Method for Structural Studies of Glycolipids.- High Resolution 1H-NMR Spectroscopy of Carbohydrate Structures.- Enzymic Degradation of Gangliosides.- Characterization of Micellar and Liposomal Dispersions of Gangliosides and Phospholipids.- Structural Modifications of Gangliosides in Synaptic Membranes.- Hydrolysis of Gangliosides in Micellar and Liposomal Dispersion by Bacterial Neuraminidases.- Distribution of Gangliosides in Tissues, Subcellular Fractions, Cells and Fluids.- Brain and Retinal Ganglioside Composition from Different Species Determined by TLC and HPTLC.- Glycolipids and Cell Differentiation.- Gangliosides of the CNS Myelin Membrane.- Gangliosides in Fish Brain.- Gangliosides of Brain and of Extraneural Tissues: Structural Relationship to Protein-Linked Glycans.- A Sensitive Assay for Gangliosides in the Subnanomole Range.- Metabolism of Gangliosides.- Introductory Remarks on Ganglioside Metabolism.- Biosynthesis of Gangliosides in Tissues.- Sialyltransferase Activities in Two Neuronal Models: Retina and Cultures of Isolated Neurons.- Sialyltransferases in Young Rat Brain.- Cell Biological and Immunological Significance of Ganglioside Changes Associated with Transformation.- Gangliosides, Neuraminidase and Sialyltransferase at the Nerve Endings.- "Neuraminidase-Resistant" Sialic Acid Residues of Gangliosides.- The Specificity of Human N-Acetyl-?-D-Hexosaminidases Towards Glycosphingolipids is Determined by an Activator Protein.- The Specificity of ?-Galactosidase in the Degradation of Gangliosides.- Immunological Methods for the Identification of Gangliosides.- Preparation and Properties of Antibodies to Gangliosides.- Antibodies to Total Brain Gangliosides: Titer and Specificity of Antisera.- Perturbation of CNS Functions by Antibodies to Gangliosides. Speculations on Biological Roles of Ganglioside Receptors.- Immunoassays Based on Plastic-Adsorbed Gangliosides.- Immunological Properties of Glycolipids Including Some Gangliosides in Mammalian Erythrocyte Membranes.- Detection of Antibodies to Gangliosides in Pathologic Human Sera. Serum-Sickness Type Heterophile Antibodies.- Sialidoses and Sialidases.- Sialidoses, New Types of Inborn Diseases.- Sialidoses (Mucolipidoses), Clinical Pictures.- Sialidase in Brain and Fibroblasts in Three Patients with Different Types of Sialidosis.- Neuraminidase Studies in Sialidosis.- Function of Gangliosides (Receptor Properties, Involvement in Neurotransmission).- Saccharide Traffic Signals in Receptor-Mediated Endocytosis and Transport of Acid Hydrolases.- Gangliosides as Receptors for Bacterial Toxins and Sendai Virus.- Isolation of Cholera Toxin by Affinity Chromatography on Porous Silica Beads with Covalently Coupled Ganglioside Gm1.- The Interaction Between Gangliosides and Interferon.- Thyrotropin Receptors and Gangliosides.- Gangliosides and Thermal Adaptation.- Neuronal and Glial Cell Cultures, a Tool for Investigation of Ganglioside Function.- Gangliosides and Synaptic Transmission.- List of Participants.- Contributor Index.
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